p 7: the effect of curcumin and melittin on an animal model of ms

Authors

masoomeh mohamadpour anatomy department, histomorphometry and stereology research center, shiraz university of medical sciences, shiraz, iran

leila kamali dolatabadi department of neuroscience, school of advanced medical sciences and technologies, histomorphometry and stereology research center, shiraz university of medical sciences, shiraz, iran

abstract

introduction: multiple sclerosis (ms) is a progressive and autoimmune neurodegenerative disease of the central nervous system (cns). this disease is renowned through symptoms like inflammation, demyelination and the damage of neurological actions. melittin is one of components of bee venom and has anti-neuroinflammatory effects. curcumin also, a dietary spice from turmeric, has outstanding anti-inflammation and neuroprotective effects. materials and methods: experimental allergic encephalomyelitis (eae) is a widely accepted animal model for ms. eae is created in animals by injecting the tissue of myelin basic protein (mbp), cns, or myelin oligodendrocyte glycoprotein (mog) along with the adjuvant. eae and ms are similar diseases. eae was induced in 40 rats randomly placed in four groups of 10: group 1: named e-s received normal saline (0.2 ml) every day. group 2: named e-mel, received 10 mg/kg melittin every day. group 3: named e-cur, received 100 mg/kg curcumin every day and group 4: named e-cur+mel .the treatments started from the first day of post immunization through gpsh-cfa and lasted until the tenth day. the elisa and the high performance liquid chromatography (hplc) were used for the assessment of tumor necrosis factor alpha (tnf-α) and nitrate in rats serum. results: in this study, we indicated that the treatment of eae with melittin and curcumin decreased the symptoms of clinical disorder, level of serum tnf-α and the serum nitrates in rat eae. conclusion: this activity of melittin and curcumin may be caused by the anti-inflammatory effects and the immuno-modulatory and antioxidant effects of these.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

P 7: The Effect of Curcumin and Melittin on an Animal Model of MS

Introduction: Multiple sclerosis (MS) is a progressive and autoimmune neurodegenerative disease of the central nervous system (CNS). This disease is renowned through symptoms like inflammation, demyelination and the damage of neurological actions. Melittin is one of components of bee venom and has anti-neuroinflammatory effects. Curcumin also, a dietary spice from turmeric, ...

full text

an investigation of the impact of self monitoring on langauge teachers motivational practice and its effect on learners motivation

the central purpose of this study was to conduct a case study about the role of self monitoring in teacher’s use of motivational strategies. furthermore it focused on how these strategies affected students’ motivational behavior. although many studies have been done to investigate teachers’ motivational strategies use (cheng & d?rnyei, 2007; d?rnyei & csizer, 1998; green, 2001, guilloteaux & d?...

the effect of using model essays on the develpment of writing proficiency of iranina pre-intermediate efl learners

abstract the present study was conducted to investigate the effect of using model essays on the development of writing proficiency of iranian pre-intermediate efl learners. to fulfill the purpose of the study, 55 pre- intermediate learners of parsa language institute were chosen by means of administering proficiency test. based on the results of the pretest, two matched groups, one as the expe...

the effect of task complexity on lexical complexity and grammatical accuracy of efl learners’ argumentative writing

بر اساس فرضیه شناخت رابینسون (2001 و 2003 و 2005) و مدل ظرفیت توجه محدود اسکهان (1998)، این تحقیق تاثیر پیچیدگی تکلیف را بر پیچیدگی واژگان و صحت گرامری نوشتار مباحثه ای 60 نفر از دانشجویان زبان انگلیسی بررسی کرد. میزان پیچیدگی تکلیف از طریق فاکتورهای پراکندگی-منابع تعیین شد. همه ی شرکت کنندگان به صورت نیمه تصادفی به یکی از سه گروه: (1) گروه موضوع، (2) گروه موضوع + اندیشه و (3) گروه موضوع + اندی...

15 صفحه اول

My Resources

Save resource for easier access later


Journal title:
مجله علوم اعصاب شفای خاتم

جلد ۵، شماره ۲، صفحات ۳۸-۳۸

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023